To ensure dissolution of the cake or powder, gently swirl each vial until complete dissolution of powder occurs (A). To reduce the total reconstitution time needed during preparation, reconstitute all required vials in succession. Slowly inject the SWFI, directing the solution onto the inside wall of the vial to minimize foaming. Use a 20-mL (or larger) syringe and 20-gauge (or higher) needle. Reconstitute the 200 mg vial of ANDEXXA with 20 mL of Sterile Water for Injection (SWFI). Table 2: ANDEXXA Dose Based on Rivaroxaban or Apixaban Dose (Timing of Last Dose of FXa Inhibitor before ANDEXXA Initiation) FXa Inhibitorĭetermine total number of vials required (see Table 1). The recommended dosing of ANDEXXA is based on the specific FXa inhibitor, dose of FXa inhibitor, and time since the patient's last dose of FXa inhibitor (see Table 2 ). 8 mg/min for up to 120 minutes (960 mg) 4 mg/min for up to 120 minutes (480 mg) * The safety and effectiveness of more than one dose have not been evaluated. Table 1: ANDEXXA Dosing Regimens Dose * The safety and efficacy of an additional dose have not been established. There are two dosing regimens (see Table 1 ).
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